Murali K Akula Selected Research

geranylgeranyltransferase type-I (protein geranylgeranyltransferase)

1/2022	Rho-GTPase dependent leukocyte interaction generates pro-inflammatory thymic Tregs and causes arthritis.
1/2019	Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation.
1/2019	Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions.
2/2013	Targeting GGTase-I activates RHOA, increases macrophage reverse cholesterol transport, and reduces atherosclerosis in mice.

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Murali K Akula Research Topics

Disease

4	Inflammation (Inflammations) 01/2022 - 02/2013
3	Atherosclerosis 01/2020 - 02/2013
2	Arthritis (Polyarthritis) 01/2022 - 01/2019
2	Rheumatoid Arthritis 01/2019 - 02/2013
1	Glucose Intolerance 01/2019
1	Atherosclerotic Plaque (Atheroma) 01/2019
1	Familial Mediterranean Fever (Periodic Disease) 01/2016
1	Melanoma (Melanoma, Malignant) 10/2015
1	Lymphatic Metastasis 10/2015
1	Neoplasm Metastasis (Metastasis) 10/2015
1	Neoplasms (Cancer) 10/2015
1	Progeria (Hutchinson Gilford Syndrome) 06/2013
1	Bone Fractures (Bone Fracture) 06/2013
1	Body Weight (Weight, Body) 06/2013

Drug/Important Bio-Agent (IBA)

4	geranylgeranyltransferase type-I (protein geranylgeranyltransferase)IBA 01/2022 - 02/2013
3	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2013
2	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 01/2022 - 01/2020
2	Proprotein Convertase 9IBA 01/2020 - 01/2019
2	LDL Receptors (LDL Receptor)IBA 01/2019 - 02/2013
2	CytokinesIBA 01/2019 - 02/2013
1	CateninsIBA 01/2022
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2019
1	CalpainIBA 01/2019
1	calpeptinIBA 01/2019
1	Guanosine Triphosphate (GTP)IBA 01/2019
1	FilaminsIBA 01/2019
1	Microfilament Proteins (Actin Binding Proteins)IBA 01/2019
1	PyrinIBA 01/2016
1	Mevalonic Acid (Mevalonate)IBA 01/2016
1	mevalonate kinaseIBA 01/2016
1	Acetylcysteine (Siran)FDA LinkGeneric 10/2015
1	AntioxidantsIBA 10/2015
1	Glutathione (Reduced Glutathione)IBA 10/2015
1	6- hydroxy- 2,5,7,8- tetramethylchroman- 2- carboxylic acid (Trolox)IBA 10/2015
1	Vitamin E FDA LinkGeneric 10/2015
1	Glutathione Disulfide (GSSG)FDA LinkGeneric 10/2015
1	prelamin AIBA 06/2013
1	protein-S-isoprenylcysteine O-methyltransferaseIBA 06/2013
1	CholesterolIBA 02/2013